Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers.Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers.However, a novel therapeutic approach is needed to further improve patient outcome with these agent
Background Irregular echinoids are ecosystem engineers with diverse functional services.Documenting present-day distribution of those widespread organisms is important for understanding their ecological significance and enhancing our ability to interpret their rich fossil record.Methods This study summarizes SCUBA surveys of clypeasteroid and spata
Wearing safety rope while working at the loft and over the side of a ship is an effective means to protect seafarers from accidents.However, there are no active and effective monitoring methods on ships to control this issue.In this article, a one-stage system LED Light is proposed to automatically monitor whether the crew is wearing safety ropes.W
ABSTRACT A major challenge faced by bacteria is infection by bacteriophage (phage).Abortive infection is one strategy for combating phage in which an infected cell kills itself to limit phage replication, thus protecting neighboring kin.One class of abortive infection systems is the cyclic oligonucleotide based anti-phage signaling system (CBASS) w
Amidst the rapidly evolving global economic landscape, the BRICS nations (Brazil, Russia, India, Vintage Parts China, and South Africa) have emerged as pivotal players, particularly in the construction sector, which serves as a cornerstone for their continued growth and development.This sector’s performance not only reflects the economic hea